A very typical case of severe cholestasis due to anabolic steroid use. Because the steroids were being used without medical supervision, the dose and actual duration of use of each preparation was unclear, but cholestasis usually arises within 4 to 12 weeks of starting a C-17 alkylated androgenic steroid. The jaundice can be severe and prolonged and accompanied by severe pruritus and marked weight loss. The serum enzymes are typically minimally elevated except for a short period immediately after stopping therapy. The pattern of enzyme elevations can be hepatocellular, cholestatic or mixed. Liver biopsy shows a “bland” cholestasis with minimal inflammation and hepatocellular necrosis. Ma Huang has also been implicated in cases of drug induced liver injury, but is associated with an acute hepatocellular pattern of injury.
There are many signals that control catabolism. Most of the known signals are hormones and the molecules involved in metabolism itself. Endocrinologists have traditionally classified many of the hormones as anabolic or catabolic, depending on which part of metabolism they stimulate. The so-called classic catabolic hormones known since the early 20th century are cortisol , glucagon , and adrenaline (and other catecholamines ). In recent decades, many more hormones with at least some catabolic effects have been discovered, including cytokines , orexin (also known as hypocretin ), and melatonin . [ citation needed ]
You should take protein and creatine as your key supplements or a Weight Gainer product if you want to gain maximum mass. Take a whey protein shake 2 to 3 times per day with one serving being just before your Halo immediately after training and take creatine monohydrate powder or a creatine tablet (like Creakic or Creadex). Start off taking 4 servings per day for the first 5 days and thereafter take 1 to 2 servings per day (2 on training days and 1 on non-training days). To gain mass at the fastest rate, you can either do the Nitro/Cell stack (Nitro 3 times per day and Cell-Tech twice on training days and once on non-training days - always take one serving of Nitro immediately, followed by Cell-Tech right after training) OR you can use a weight gainer like Mutant Mass (along with powdered creatine) or Mass-Tech or Muscle Fuel Anabolic (which already contain creatine). If your diet is good (high in calories and protein), go with the Nitro/Cell stack, if your diet isn't so good, go with one of the mass gainers - start off with 2 to 3 scoops twice daily and increase until you are gaining the desired amount of weight per week (1/2 to 2 kilos).