Astepro nasal spray steroid

The systemic bioavailability of azelastine is approximately 40% when administered intranasally. Maximum plasma concentrations (Cmax) are observed within 2–3 hours. The elimination half life , steady-state volume of distribution and plasma clearance are 22 h, l/kg and l/h/kg respectively (based on intravenous and oral administration data). Azelastine is oxidatively metabolized by the cytochrome P450 family into its active metabolite, desmethylazelastine, and two inactive carboxylic acid metabolites. Approximately 75% of an oral dose is excreted in feces. Pharmacokinetics of orally administered azelastine are not affected by age, gender or hepatic impairment. [12]

During the post approval use of ASTEPRO % and ASTEPRO %, the following adverse reactions have been identified. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse reactions reported include: abdominal pain, atrial fibrillation , blurred vision, chest pain, confusion, disturbance or loss of sense of smell and/or taste, dizziness, dyspnea , facial swelling, hypertension , involuntary muscle contractions, nasal burning, nausea, nervousness, palpitations , paresthesia , parosmia, pruritus , rash, sneezing, insomnia, sweet taste, tachycardia , and throat irritation.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Astepro nasal spray steroid

astepro nasal spray steroid


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