Biotransformation of terpenes and steroids

Exposure to bifenthrin can be achieved either by skin contact or ingestion. Skin contact is not toxic, apart from a slight tingling sensation on the specific location of contact. Ingestion is toxic, although only slightly. Commercially available bifenthrin (Ortho Home Defense Max, for example), however, can induce toxic effects in those concentrations, because the added chemicals which improve the sustainability either potentiate bifenthrin or are toxic on their own. Symptoms of excessive exposure are nausea, headaches, hypersensitivity for touch and sound, and irritation of the skin and the eyes. [14]

Biotransformation of ftorafir (FT) was studied using 2-14C-ftorafur and 2;5'-14C-ftorafur. Both pyrimidine and tetrahydrofurane moieties of the FT underwent degradation to CO2 in rats. The cleavage of the pseudoglycosidic bonds C-N and formation of 5-fluorouracil was one of the steps of the FT metabolism that limited the velocity of the whole biotransformation process. Liver tissue NADPH-linked monooxygenating system was shown to participate in the process. The data obtained suggest that the role of enzymes involved in metabolism of nucleic acids was not significant in the FT metabolism under the conditions studied in vivo.

Biotransformation of terpenes and steroids

biotransformation of terpenes and steroids

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