Chlorogenic acid and oxypregnane steroidal glycoside

Total homocysteine in plasma collected 4-5 h after supplement intake was 12% ( micromol/L; 95% CI: , ) higher after chlorogenic acid and 11% ( micromol/L; 95% CI: , ) higher after black tea than after placebo. Total homocysteine in fasting plasma collected 20 h after supplement intake was 4% ( micromol/L; 95% CI: , ) higher after chlorogenic acid and 5% ( micromol/L; 95% CI: , ) higher after black tea than after placebo. Quercetin-3-rutinoside did not significantly affect homocysteine concentrations.

Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption. In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.

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Chlorogenic acid and oxypregnane steroidal glycoside

chlorogenic acid and oxypregnane steroidal glycoside

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