Diprogenta Cream (Betamethasone dipropionate) Betamethasone is an artificial corticosteroid that is applied on the skin (topically). Betamethasone impersonates the effect of hydrocortisone (cortisol), the steroid generated naturally in the human system by the adrenal glands. Corticosteroids contain effective anti-provocative effects and also restrain the immune reaction. Corticosteroids have a lot of effects on the human system, but they mainly are applied for their powerful anti-inflammatory actions, predominantly in those situations in which the immune system plays a significant part. Betamethasone dipropionate was approved by the FDA in July 1983.
In clinical trials of tinea corporis, tinea cruris, and tinea pedis, subjects treated with LOTRISONE cream showed a better clinical response at the first return visit than subjects treated with clotrimazole cream. In tinea corporis and tinea cruris, the subject returned 3 to 5 days after starting treatment, and in tinea pedis, after 1 week. Mycological cure rates observed in subjects treated with LOTRISONE cream were as good as, or better than, in those subjects treated with clotrimazole cream. In these same clinical studies, patients treated with LOTRISONE cream showed better clinical responses and mycological cure rates when compared with subjects treated with betamethasone dipropionate cream.