Third, GH may influence the activity of IGF-1 on an autocrine/paracrine level. Autocrine means that a hormone has an effect on the cell that produced it, paracrine means to have an effect on the “cell(s)” next to it as well. This is a completely localized effect, not dependent on the blood stream to carry things where you want them. Muscle growth from weight training is the result of IGF-1 being produced by the muscle cells themselves, not the liver. In fact, IGF-1 form the liver is genetically different from IGF-1 produced in your muscles. This information should explain why using IGF-1 systemically (from the blood stream) has been a hit and miss proposition.
If I BB’r really wanted to get crazy he might combine 2 injectables and maybe 2 orals (most BB’rs in that day used only one oral at a time)…and the total dosage might reach 1,500 mg weekly. However, this was not the norm and was considered excessive by most. I am sure at least a few people reading article this will call bullshit because they know of someone who used more, but like I said, there have always been guys who have pushed the dosing envelope in their generation. However, these men do not adequately represent the average BB’r of their era. They are the exception, not the rule.