The efficacy and safety of azelastine hydrochloride nasal spray, % with sweetener in seasonal allergic rhinitis was evaluated in five randomized, multicenter, double-blind, placebo-controlled clinical trials in 2499 adult and adolescent patients 12 years and older with symptoms of seasonal allergic rhinitis (Trials 2, 3, 4, 5, and 6). The population of the trials was 12 to 83 years of age (64% female, 36% male; 81% white, 12% black, <2% Asian, 5% other; 23% Hispanic, 77% non-Hispanic). Assessment of efficacy was based on the rTNSS, iTNSS as described above, and other supportive secondary efficacy variables. The primary efficacy endpoint was the mean change from baseline in rTNSS over 2 weeks.
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Antihistamines work by blocking histamine, a substance produced by your cells to prevent infection.  If your body detects a foreign substance, your cells will make histamine, which causes inflammation of blood vessels. Usually this is useful. But when your body mistakes a non-harmful substance, like pollen, for a harmful one, it can cause what we call seasonal allergies.  Antihistamines are commonly known for treating seasonal allergies, but there are several other uses for both over-the-counter antihistamines and those prescribed by a doctor. Before taking antihistamines, understand how antihistamines work and what symptoms they treat.