Microdermal implants are a more desirable alternative to surface piercings , as they provide less scarring when removed. They are semi-permanent and can be removed with the assistance of a professional. Implants should be left alone and covered for the first 3–6 months as they are susceptible to outside damage (tugging, pulling and catching, which move the implant closer to the surface of the skin). Also, the body naturally rejects foreign objects, so it is crucial for the piercings to go as deep as possible. In order to combat these effects constant modification to the jewelry is being made; the latest use large holes in the anchors to encourage tissue to grow through to hold the jewelry in place.
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Topical ocular administration of % dexamethasone ( mg/kg/day) on gestational days 10 to 13 produced embryofetal lethality and a high incidence of cleft palate in mice. A dose of mg/kg/day in the mouse is approximately 3 times an OZURDEX ® injection in humans ( mg dexamethasone) on a mg/m2 basis. In rabbits, topical ocular administration of % dexamethasone throughout organogenesis ( mg/kg/day, on gestational day 6 followed by mg/kg/day on gestational days 7-18) produced intestinal anomalies, intestinal aplasia, gastroschisis and hypoplastic kidneys. A dose of mg/kg/day in the rabbit is approximately 4 times an OZURDEX ® injection in humans ( mg dexamethasone) on a mg/m2 basis.