Sentara Healthcare , based in Norfolk, VA, celebrates more than 125 years in pursuit of its mission to improve health every day. Sentara is an integrated not-for-profit system of 12 hospitals in Virginia and North Carolina, including a Level I trauma center with Nightingale Regional Air Ambulance . The Sentara family also includes four medical groups, ambulatory campuses, post-acute care services, the physician-led Sentara Quality Care Network , the Sentara College of Health Sciences , Optima Health Plan members in Virginia, Alabama and Ohio, and a team of professionals nearly 28,000 strong. Sentara is strategically focused on continuous improvement in quality, safety, innovation and the patient experience.
Several brands of IVIG have been approved by the Food and Drug Adminsitration (FDA) (see table in Appendix). There is a lack of reliable evidence that any one brand of IVIG is more effective than other brands. However, immune globulin products may differ from each other in ways that may be important in a particular patient. Different manufacturers then use various combinations of precipitation and/or chromatography steps to obtain a final preparation that consists of greater than 95 % IgG in all currently available products. The various manufacturers also use different final purification steps and stabilizers to obtain their final products, which may then vary in storage requirement and shelf life. In several currently available products, stabilizers include sugars, such as sucrose, glucose, or maltose. Other products contain amino acids such as glycine and proline. The sodium content of different products also varies.
IMPORTANT SAFETY INFORMATION
BOTOX ® Cosmetic may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX ® Cosmetic:
• Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months
• Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice (dysphonia), trouble saying words clearly (dysarthria), loss of bladder control, trouble breathing, trouble swallowing. If this happens, do not drive a car, operate machinery, or do other dangerous activities. The dose of BOTOX ® Cosmetic is not the same as, or comparable to, any other botulinum toxin product.