Mees lines are transverse white lines that may extend the complete width of the nail plate. The lines can occur on a single digit or multiple digits. Mees lines migrate toward the distal end of the nail plate over time because the abnormality is in the nail plate and not the nail bed. The differential diagnosis for Mees lines is narrow, and it is thought to be caused primarily by arsenic poisoning. 1 Other heavy metal poisonings and renal failure also may result in Mees lines. 11 The timing of the poisoning can be estimated based on the rate of nail plate growth. 1
Observed baseline and 3-week mean ODI scores were and for the prednisone group and and for the placebo group, respectively. The prednisone-treated group showed an adjusted mean -point (95% CI, -; P = .006) greater improvement in ODI scores at 3 weeks than the placebo group and a mean -point (95% CI, -; P = .005) greater improvement at 52 weeks. Compared with the placebo group, the prednisone group showed an adjusted mean -point (95% CI, - to ; P = .34) greater reduction in pain at 3 weeks and a mean -point (95% CI, - to ; P = .15) greater reduction at 52 weeks. The prednisone group showed an adjusted mean -point (95% CI, -; P = .001) greater improvement in the SF-36 PCS score at 3 weeks, no difference in the SF-36 PCS score at 52 weeks (mean, ; 95% CI, - to ; P = .08), no change in the SF-36 MCS score at 3 weeks (mean, ; 95% CI, - to ; P = .10), and an adjusted -point (95% CI, -; P = .02) greater improvement in the SF-36 MCS score at 52 weeks. There were no differences in surgery rates at 52-week follow-up. Having 1 or more adverse events at 3-week follow-up was more common in the prednisone group than in the placebo group (% vs %; P < .001).