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Mortuaire, G., de Gabory, L., François, M., Massé, G., Bloch, F., Brion, N., ... Serrano, E. Rebound congestion and rhinitis medicamentosa: Nasal decongestants in clinical practice. (2013, June 1). Critical review of the literature by a medical panel. European Annals of Otorhinolaryngology, Head and Neck Diseases , 130(3), 137-144. Retrieved from https:///#!/content/playContent/1--S1879729612001378?returnurl=http:%2F%%2Fretrieve%2Fpii%2FS1879729612001378%3Fshowall%3Dtrue&referrer=https:%2F%2F .

After subcutaneous administration of 14 C-nafarelin acetate to men, 44–55% of the dose was recovered in urine and –% was recovered in feces. Approximately 3% of the administered dose appeared as unchanged nafarelin in urine. The 14C serum half-life of the metabolites was about hours. Six metabolites of nafarelin have been identified of which the major metabolite is Tyr-D(2)-Nal-Leu-Arg-Pro-Gly-NH2(5-10). The activity of the metabolites, the metabolism of nafarelin by nasal mucosa , and the pharmacoki netics of the drug in hepatically- and renally-impaired patients have not been determined.

OVERVIEW
FLOSaline+Plus is a sterile, preservative-free, non-medicated, isotonic nasal saline spray with added minerals, designed to naturally relieve nasal congestion caused from:
• Colds & flu
• Rhinitis – inflammation of the nose tissues
• Sinusitis
• Hayfever
• Nasal surgery
• Pregnancy
FLO Saline+Plus may also be used by pregnant mothers, and people with sensitive noses because it does not contain any preservatives, alcohol, chemicals or buffers.
FLO Saline+Plus helps reduce nasal congestion by flushing the nose and thinning mucus. Cleansing the nasal tissue helps to remove inflammatory cells and their by-products to improve overall nasal tissue function.
FLO Saline+Plus is non-medicated and does not contain any chemicals or preservatives so you can use it as often as needed to relieve nasal congestion. FLO Saline+Plus may be used with other medicated nasal sprays (decongestants, antihistamines and steroids) to help keep your nose clean and clear. Use FLO Saline+Plus 10-15 minutes before a medicated nasal spray to cleanse the nasal tissues and help improve the effectiveness of the medicated spray.
Many nasal sprays contain preservatives and chemicals. FLO Saline+Plus has a unique pump delivery system to keep the solution sterile without the need for added preservatives and chemicals.
Always remember to read the label and use as directed. Consult your healthcare professional if symptoms persist.

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