Alternatives: As with insomnia (see benzodiazepine hypnotics, above), it's important to identify the cause of excessive daytime sleepiness. Other medications you're taking — whether prescription or over the counter — could be responsible. Drugs with sedating effects, for example, are among the most common causes of excessive daytime sleepiness. (These include alpha- and beta-blockers, anti-diarrheal agents, antihistamines, antipsychotics, antispasmodics, cough suppressants, epilepsy drugs, skeletal muscle relaxants, Parkinson's drugs and some antidepressant medications.)
The most significant factor in the connection between cortisone and depression appears to be the dosage. The higher the dosage, the more likely the appearance of side effects with the majority of them occurring early in the therapy. Should cortisone cause mental disorders such as depression, the drug is usually reduced or stopped altogether. However, another link between cortisone and depression is that a rapid or substantial reduction in cortisone may also cause severe changes in mental state. For this reason, care must be taken and the withdrawal closely monitored.